Mashpee is a town in Barnstable County, Massachusetts, United States, on Cape Cod. The population was 14,006 as of 2010. It is the site of the headquarters and most members of the federally recognized Mashpee Wampanoag Tribe, one of two Wampanoag.

For geographic and demographic information on specific parts of the town of Mashpee, please see the articles on Mashpee Neck, Monomoscoy Island, New Seabury, Popponesset, Popponesset Island, Seabrook, and Seconsett Island.

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According to the United States Census Bureau, Mashpee has a total area of 27.2 square miles (70.5 km2), of which 23.4 square miles (60.6 km2) is land and 3.8 square miles (9.9 km2), or 14.10%, is water.

Mashpee is on the "upper," or western, portion of Cape Cod. It is bounded by Sandwich to the north and northwest, Barnstable to the east, Nantucket Sound to the south, and Falmouthto the west. It is approximately 65 miles (105 km) south-southeast of Boston and 70 miles (110 km) east-southeast of Providence, Rhode Island.

Like all towns on the Cape, Mashpee's topography is that of sandy soil, small ponds and inlets, surrounded by the pines and oaks indigenous to the area. The town's shoreline is framed by Waquoit Bay to the west and Popponesset Bay to the east, with several rivers, brooks and small ponds in the area. The town contains South Cape Beach State Park along Dead Neck and Waquoit Bay, and the Lowell Holly Reservation, comprising the land between Wakeby and Mashpee Ponds.

Mashpee also borders a small area of Otis Air National Guard Base, Joint Base Cape Cod, and Camp Edwards in the northwest portion of the town.

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